Combination of sedating and non sedating antihistamines
The newer antihistamines are less prone to cause sedation orantirnuscarinic effects.
The role of histamine in dermatopathology The highest concentration of histamine is found in the lungs, skin and intestinal mucosa.
Their effective duration of action is four to six hours, but the newer Hi blockers have a duration of 12 to 24 hours. et al Hypothalamic - pituitary-gonadal dysfunction in men using cimetidine.
Many antihistamines cause some degree of sedation to which tolerance generally develops.
Other adverse effects include antimuscarinic, extrapy ramidal symptoms and hypersensitivity reactions.
Ethanolamines Carbinoxamine (clistin): Antimuscarinic, central sedative and antiserotinin effects, 2-4 mg three to four times daily.
Diphenhydramine (Benadryl): Antimuscarinic, marked central sedation and antiemetic effects, 25-50 mg three to four times daily. marked central sedation, antiemetic effects, 50-100 mg three to four times daily.
rhinitis, conjunctivitis and pruritus associated with skin disorders.